Depression in adults: recognition and management : guidance (CG90)

National Institute for Health and Care Excellence - NICE
Publication date:
28 October 2009


This guideline covers identifying and managing depression in adults aged 18 years and older, in primary and secondary care. It aims to improve care for people with depression by promoting improved recognition and treatment.

 MHRA advice on valproate: In April 2018, we added warnings that valproate must not be used in pregnancy, and only used in girls and women when there is no alternative and a pregnancy prevention plan is in place. This is because of the risk of malformations and developmental abnormalities in the baby. See update information for details. In March 2019, we produced a summary of NICE guidance to support the safe use of valproate.

NICE has also produced a guideline on depression in adults with a chronic physical health problem (NICE guideline CG91).


This guideline includes recommendations on:

Who is it for?

  • Healthcare professionals
  • People with depression, their families and carers

Is this guideline up to date?

We reviewed the evidence in December 2013 and we are updating this guideline. See the guideline in development page for progress on the update.

Guideline development process

How we develop NICE guidelines 

This guideline updates and replaces NICE guideline CG23 (December 2004).