Complex regional pain syndrome (CPRS) is characterised by pain and a variety of other local symptoms that are disproportionate to the injury sustained. This comprehensive review identified a number of systematic reviews of clinical evidence. However, despite the identification of numerous papers in the area, there was insufficient evidence to recommend an effective treatment approach. There is low quality evidence for several treatment options and no firm recommendations could be made about their efficacy and use. However, moderate quality evidence suggests intravenous regional blockade with guanethidine is not effective and may be associated with complications.