This report has been prepared by a multiprofessional collaborative group, with support from the All Wales Prescribing Advisory Group (AWPAG) and the All Wales Therapeutics and Toxicology Centre (AWTTC), and has subsequently been endorsed by the All Wales Medicines Strategy Group (AWMSG). It summarises the AWMSG National Prescribing Indicators (NPIs) for 2015-2016 and provides points for consideration and links to supporting materials.