This guideline aims to assist endoscopists in providing care to patients. It describes various endoscopic tests for the diagnosis and treatment of obscure GI bleeding (OGIB) including video capsule and push endoscopy, deep enteroscopy, nuclear scan, angiography and CT imaging. Obscure gastrointestinal bleeding is also referred to as occult or overt bleeding of unknown origin that continues after a negative endoscopic evaluation such as colonoscopy or esophagogastroduodenoscopy. This guideline is an update of the 2003 guideline published by the American Society for Gastrointestinal Endoscopy. It describes the performance characteristics of various endoscopic and nonendoscopic tests, and makes recommendations for diagnostics practice.