[PDF] Evidence-based clinical practice guideline : inhaled nitric oxide for neonates with acute hypoxic respiratory failure

Source:
American Association for Respiratory Care
Publisher:
American Association for Respiratory Care
Publication date:
01 December 2010

Abstract

DiBlasi RM, Myers TR, Hess DR (2010) Evidence-based clinical practice guideline: inhaled nitric oxide for neonates with acute hypoxic respiratory failure. Respiratory Care 55: 1717-1745

Neonatal hypoxic respiratory failure may be caused by persistent pulmonary hypertension of the newborn (PPHN) and other diseases that contribute to pulmonary arterial hypertension. Inhaled nitric oxide (INO) can decrease pulmonary vascular resistance, improve ventilation-perfusion inequalities, and reduce right-to-left intra-cardiac shunting of blood through the foramen ovale and ductus arteriosus, all of which can contribute to improved arterial oxygenation and hemodynamic stability.