SCoR publishes this guidance document to support development of therapeutic radiography services. Since 1997 when SCoR published Therapeutic Radiography: A Vision for the Future, guidance and advice documents have been published which have defined the direction of travel for therapeutic radiographers and supported them to embrace change in order to respond and to deliver patient-centred care. This document supersedes and replaces existing SCoR therapeutic radiography guidance. It outlines the practice of therapeutic radiography in providing high quality care to patients while continuing to develop the scope of practice of therapeutic radiography, safely and effectivelywhen working as a critical part of the radiotherapy team and responding to the challenges of a changing health care provider environment. It builds on the recently published SCoR’s ‘Principles of safe staffing for radiography leaders’ guidance, informs the therapeutic radiography profession and supports the head of radiotherapy (radiotherapy service manager) by outlining the principles to be considered with regards to the therapeutic radiography workforce.