This PBM implementation guide was developed as a supporting tool for hospitals in the implementation of PBM at the operational level. It has taken inspiration from successfully implemented programmes in different parts of the world, recommending a well-recognised model for introducing change. It is acknowledged that alternative change management models could also be applied successfully. The guide focuses on how to implement the PBM concept in hospitals in a practical way, building on already recognised best practices (44-47). It does not aim to review the clinical evidence for PBM or to provide clinical PBM guidelines. A substantial list of publications that provide the rationale for PBM and that define good clinical practice supporting PBM is included at the end of this document.