Community-associated methicillin-resistant Staphylococus Aureus (CA-MRSA) infections have emerged as a significant issue in some Indigenous communities (including First Nations, Inuit and Métis) in Canada. Primarily associated with skin and soft-tissue infections, the organism can also result in significant morbidity and mortality. Canadian and American guidelines for managing CA-MRSA infections have been published. The specific epidemiology, microbiology and susceptibility patterns, and the social/environmental circumstances of CA-MRSA infections in Indigenous communities need to be considered for strategies to reduce transmission. Reducing household crowding and improving in-home potable water supply are optimal strategies to reduce the impact of this illness. Implementing Canadian guidelines along with increased prevention strategies are recommended as interim measures.