Previous US guidelines on perioperative care for colon and rectal surgery included studies identified up to January 2012 with significant literature published since then. The combined ASCRS/SAGES committee was created to define current best-quality care for enhanced recovery after colon and rectal surgery. This clinical practice guideline is based on the best available evidence. The guidelines are inclusive and not prescriptive and their purpose is to provide information on which decisions can be made rather than to dictate a specific form of treatment. The guidelines are intended for the use of all practitioners, healthcare workers, and patients who desire information about the management of the conditions addressed by the topics covered in these guidelines.