Safety in Lactation: Drugs for bipolar disorder and hypomania
Published 3rd January 2018 , updated 28th November 2018
Additional information relating to breastfeeding
T o be used in conjunction with individual drug entries for specific information and guidance.
Whilst valproate (valproic acid/sodium valproate) is a suitable choice for use during breast feeding, current MHRA advice states that it should not be used in women of child bearing age unless Pregnancy Prevention Programme is in place, and only if other treatments are ineffective or not tolerated. For this reason, carbamazepine is preferred first-line in breastfeeding.
Lithium must be used with extreme caution, and the mother must be able to comply with strict monitoring conditions.
With all antimanic drugs, infants should be monitored for sedation, poor feeding, behavioural effects and developmental milestones. There is limited data on the neurodevelopmental effects of long-term exposure to these agents during breastfeeding.
Antipsychotics may also be used in the management of mania and hypomania and may, in some clinical situations, be more appropriate alternatives – see separate section
Asenapine Carbamazepine Lithium carbonate Lithium citrate Mental health and illness Obstetrics and gynaecology Paediatric and neonatal medicine Safety in Lactation Sodium valproate Valproic acid