[PDF] Pharmacogenetics

International Association for the Study of Pain
International Association for the Study of Pain (IASP)
Publication date:
31 August 2010


Analgesic drug dosing requirements to produce satisfactory pain relief with tolerable side-effects are subject to considerable interindividual variability, even in patients with pain of an apparently similar type and intensity. Contributing factors include those of genetic and environmental origin as well as their interaction. Environmental factors include patient age, sex, status of liver and kidney function, lifestyle variables such as smoking and alcohol consumption, disease comorbidities, and concurrent medications. Genetic factors include those related to the regulation of analgesic drug pharmacodynamics and pharmacokinetics.