Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator

American Heart Association
American Heart Association
Publication date:
28 May 2009


Each year around 795,000 strokes occur in the United States of America, and of these approximately 600,000 are ischemic.  Current guidelines recommend administration of tissue plasminogen activator (rtPA) for acute ischemic stroke within three hours of stroke symptom onset.  Recent results of the European Cooperative Acute Stroke Study (ECASS-3) show evidence of an expanded time window between 3.0 and 4.5 hours for persons experiencing acute ischemic stroke symptoms.

Includes sections on:

  • Top things to know
  • Slide set
  • Guidelines for the Early Management of Adults with Ischemic Stroke
  • Other AHA/ASA statements and guidelines for stroke