(2014) Guideline 140: Management of primary cutaneous squamous cell carcinoma - Full guideline. The Scottish Intercollegiate Guidelines Network (SIGN) develops evidence based clinical practice guidelines for the National Health Service (NHS) in Scotland. SIGN guidelines are derived from a systematic review of the scientific literature and are designed as a vehicle for accelerating the translation of new knowledge into action to meet our aim of reducing variations in practice, and improving patient-important outcomes.
This guideline provides recommendations for referral, management and follow up of patients aged 18 years and over with primary invasive cutaneous squamous cell carcinoma (SCC), including SCC arising: on sun-exposed (SE) and non-SE sites. The guideline addresses pathological, clinical and tumour features, or combination of features that best facilitate risk stratification in patients with primary invasive cutaneous SCC. It includes a management algorithm and pathological reporting proforma.