Abstract

RCT (n=107) found low-dose imipramine (25mg/night for first 2 weeks then 50mg thereafter) was linked to higher rate of relief of global dyspepsia symptoms at 12 weeks vs. placebo (35 [63·6%] vs. 19 [36·5%]; p=0·0051). More patients on imipramine discontinued study due to ADRs