Meta-analysis: Subclinical Thyroid Dysfunction and the Risk for Coronary Heart Disease and Mortality

American College of Physicians
American College of Physicians
Publication date:
19 May 2008



Specialist Library Quality Assessment: The review addressed a clearly focused question and included appropriate aetiological studies. The search was restricted to a single database, but was extended to all languages and reference lists of studies were followed up. Two reviewers independently screened the abstracts and titles of the search results and eliminated articles not meeting the inclusion criteria. The same 2 reviewers independently evaluated the remaining full-text articles for eligibility on the basis of a predefined set of eligibility criteria.  Tests for heterogeneity were conducted, and sensitivity and subgroup analysis were conducted using random-effects models to explore variations further. The authors acknowledged that individual studies adjusted for different potential confounders, and 1 study provided only unadjusted data. Publication bias or selective reporting of outcomes could not be excluded. Given these limitations and the single database searched, the authors' cautious conclusions are justified.


Citation: Ochs N, Auer R, Bauer DC, Nanchen D, Gussekloo J, Cornuz J, Rodondi N. Meta-analysis: Subclinical Thyroid Dysfunction and the Risk for Coronary Heart Disease and Mortality. Ann Intern Med. 2008 Jun 3;148(11):832-45.

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