This guideline is intended to be a resource for the clinical and public health practice communities. It addresses the primary prevention of cardiovascuar diseases (CVD) in adults (=18 years of age), focused on outcomes of ASCVD (i.e. acute coronary syndromes, myocardial infarction (M), stable or unstable angina, arterial revascularization, stroke, transient ischemic attack, or peripheral arterial disease of atherosclerotic origin), as well as heart failure and atrial fibrillation. It presents recommendations to prevent CVD that are related to lifestyle factors (e.g. diet and exercise or physical activity), other factors affecting CVD risk (e.g. obesity, diabetes, blood cholesterol, high blood pressure, smoking, aspirin use), patient-centred approaches (e.g. team-based care, shared decision-making, assessment of social determinants of health), and considerations of the cost and value of primary prevention.