These guidelines provide a comprehensive set of WHO recommendations for programmatic management of LTBI and the basis and rationale for national guidelines. These guidelines supersede previous WHO policy documents on the management of LTBI in people living with HIV and household contacts of people with TB and other at-risk groups. The guidelines were prepared in accordance with the requirements and recommended process of the WHO Guideline Review Committee. Seven systematic reviews were conducted to update the recommendations and make new ones. The Guideline Development Group considered the quality of the evidence, benefits and harms, values and preferences, equity, costs, acceptability and feasibility of implementation in formulating the recommendations and determining their strength.