Revised SPC: Lyrica (pregabalin) 20 mg/ml oral solution and hard capsules (all strengths)
electronic Medicines Compendium - eMC
electronic Medicines compendium
14 January 2020
Sections 4.4 and 4.5 advise caution when used with opioids due to risk of CNS depression - this increased risk was observed at low doses of pregabalin (= 300 mg) and there was a trend for a greater risk at high doses of pregabalin.