Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes

Record type Uncertainties identified in research recommendations
Source Cochrane Pregnancy and Childbirth Group
Why is there uncertainty? Reliable up-to-date systematic reviews have revealed important continuing uncertainties about treatment effects

Original Uncertainty

Implications for Research Although the currently available evidence indicates that antenatal supplementation with myo-inositol may be beneficial in reducing the incidence of GDM, the effect on important neonatal outcomes is unclear. Further well-designed randomised controlled trials are required, and should be sufficiently powered to detect differences in relevant maternal and neonatal outcomes. They should include participants of varying ethnicities and with various risk factors for GDM, such as obesity, polycystic ovarian syndrome, family history, and previous GDM, and explore the optimal dose, frequency and timing of supplementation. It is important that trials report on potential harms including adverse effects. In view of the availability of myo-inositol as a dietary supplement and its relatively low cost compared with traditional interventions for preventing GDM, future randomised controlled trials should include an economic analysis, or at least report on health service use and costs. If the efficacy of antenatal supplementation with myo-inositol compared with placebo is established, then it will also be useful to conduct trials that compare the use of myo-inositol with other preventative interventions such as lifestyle (diet and exercise) or pharmacological interventions such as metformin.

References to reliable up-to-date systematic reviews:

Crawford TJ, Crowther CA, Alsweiler J, Brown J. Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes. Cochrane Database of Systematic Reviews 2015, Issue 12. Art. No.: CD011507. DOI: 10.1002/14651858.CD011507.pub2

What is needed? Further research
Systematic reviews that need updating or extending None identified
Systematic reviews in preparation None identified
Ongoing controlled trials A randomised controlled trial to investigate the role of the food supplement inositol in the general health of those at risk of developing gestational diabetes mellitus ISRCTN92466608


Which health conditions? Nutritional metabolic and endocrine disorders | Diabetes | Gestational diabetes
What is person's age? Infant/Adult
Which types of treatments? Diet | Drug

Which Outcomes

Incidence of gestational diabetes: change in symptoms, or change in management of symptoms (glucose intolerance, incidence of hypertensive disorders of pregnancy, neonatal outcomes (large-for-gestational age, perinatal mortality, mortality or morbidity composite), incidence of caesarean section, incience of macrosomia, neonatal hypoglycaemia, shoulder dystocia, long-term childhood or adulthood outcomes); adverse effects or complications; patient satisfaction; health related quality of life; service related issues; and health related cost

Record ID: Publication date:10 Mar 2016
Last reviewed date:10 Mar 2017 Publication Type:Known Uncertainty
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