Antibiotic prophylaxis for surgical site infection in people undergoing liver transplantation

Record type Uncertainties identified in research recommendations
Source Cochrane Hepato-Biliary Group
Why is there uncertainty? Reliable up-to-date systematic reviews have revealed important continuing uncertainties about treatment effects

Original Uncertainty

Implications for Research This review highlights the need for continued research on administration of antibiotics for prophylaxis of surgical site infection in patients undergoing liver transplantation. Additional well-conducted randomised clinical trials are needed to determine the exact role of antibiotics in the algorithm for prevention of surgical site infection in liver transplantation (CONSORT Statement; SPIRIT Statement). These trials should be conducted with consideration of different scenarios and risk factors as the source of epidemiological data on specific hospital and individual flora, previous use of antibiotics, retransplantation, red blood cell transfusions, specific surgical techniques and clinical status, among others.

References to reliable up-to-date systematic reviews:

Almeida RAMB, Hasimoto CN, Kim A, Hasimoto EN, El Dib R. Antibiotic prophylaxis for surgical site infection in people undergoing liver transplantation. Cochrane Database of Systematic Reviews 2015, Issue 12. Art. No.: CD010164. DOI: 10.1002/14651858.CD010164.pub2

What is needed? Further research
Systematic reviews that need updating or extending None identified
Systematic reviews in preparation None identified
Ongoing controlled trials None identified


Which health conditions? Gastroenterological and liver diseases | Liver transplantation
What is person's age? Any age
Which types of treatments? Drug

Which Outcomes

Incidence of surgical site infection: change in symptoms, or change in management of symptoms; adverse effects or complications; patient satisfaction; health related quality of life; service related issues; and health related cost

Record ID: Publication date:10 Mar 2016
Last reviewed date:10 Mar 2017 Publication Type:Known Uncertainty
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