Add this result to my export selection Intravenous versus intramuscular prophylactic oxytocin for reducing blood loss in the third stage of labour Source: Cochrane Database of Systematic Reviews (Remove filter) Published by Cochrane Database of Systematic Reviews, 10 December 2020 This review (7 trials; n=7,817) found IV administration of oxytocin is more effective than intramuscular administration in preventing postpartum haemorrhage during vaginal birth, with a comparable... Read Summary Type: Systematic Reviews (Add filter) Type: Medicines Current Awareness (Remove filter)
Add this result to my export selection Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants (most commonly F508del) Source: Cochrane Database of Systematic Reviews (Remove filter) Published by Cochrane Database of Systematic Reviews, 17 December 2020 This review of 19 RCTs (n=2959) found there is insufficient evidence that corrector monotherapy has clinically important effects in pwCF with F508del/F508del. Further RCTs are required in children... Read Summary Type: Systematic Reviews (Add filter) Type: Medicines Current Awareness (Remove filter)
Add this result to my export selection Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy Source: Cochrane Database of Systematic Reviews (Remove filter) Published by Cochrane Database of Systematic Reviews, 14 December 2020 This review of 34 studies (n=1960) found the available evidence does not support the superiority of any anticoagulant to another. Further studies are needed to identify patient populations in which... Read Summary Type: Systematic Reviews (Add filter) Type: Medicines Current Awareness (Remove filter)
Add this result to my export selection Melatonin for preoperative and postoperative anxiety in adults Source: Cochrane Database of Systematic Reviews (Remove filter) Published by Cochrane Database of Systematic Reviews, 08 February 2021 Review (27 RCTs; n=2319) found melatonin given as premedication probably reduces preoperative anxiety in adults vs placebo, with a smaller effect on postoperative anxiety. There was little or no... Read Summary Type: Systematic Reviews (Add filter) Type: Medicines Current Awareness (Remove filter)
Add this result to my export selection Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth Source: Cochrane Database of Systematic Reviews (Remove filter) Published by Cochrane Database of Systematic Reviews, 25 December 2020 Evidence from updated review (27 studies, n=11,272 women and 11,925 neonates) supports continued use of single course of antenatal corticosteroids to accelerate foetal lung maturation. Treatment... Read Summary Type: Systematic Reviews (Add filter) Type: Medicines Current Awareness (Remove filter)
Add this result to my export selection Anti‐IL‐5 therapies for chronic obstructive pulmonary disease Source: Cochrane Database of Systematic Reviews (Remove filter) Published by Cochrane Database of Systematic Reviews, 08 December 2020 Review (6 studies, n=5542) found mepolizumab and benralizumab probably reduce the rate of moderate and severe exacerbations in the highly selected group of people who have both COPD and higher levels... Read Summary Type: Systematic Reviews (Add filter) Type: Medicines Current Awareness (Remove filter)
Add this result to my export selection Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome Source: Cochrane Database of Systematic Reviews (Remove filter) Published by Cochrane Database of Systematic Reviews, 21 December 2020 This updated review (13 RCTs; n=1132) found no conclusive evidence that use of metformin before or during IVF/ICSI treatment in women with PCOS improves live birth rates. It may reduce incidence of... Read Summary Type: Systematic Reviews (Add filter) Type: Medicines Current Awareness (Remove filter)
Add this result to my export selection Interventions for frostbite injuries Source: Cochrane Database of Systematic Reviews (Remove filter) Published by Cochrane Database of Systematic Reviews, 20 February 2021 Review (one RCT; n=47) found limited, very low-quality evidence that iloprost ± recombinant tissue plasminogen activator, in combination with buflomedil, may reduce need for amputation in severe... Read Summary Type: Systematic Reviews (Add filter) Type: Medicines Current Awareness (Remove filter)
Add this result to my export selection Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy Source: Cochrane Database of Systematic Reviews (Remove filter) Published by Cochrane Database of Systematic Reviews, 18 February 2021 This updated review (32 RCTs [6 new]; n=15,678) found LMWH reduce, and direct factor Xa inhibitors may reduce, incidence of symptomatic VTE; both likely increase risk of major bleeding. Evidence for... Read Summary Type: Systematic Reviews (Add filter) Type: Medicines Current Awareness (Remove filter)
Add this result to my export selection Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride Source: Cochrane Database of Systematic Reviews (Remove filter) Published by Cochrane Database of Systematic Reviews, 12 December 2020 Updated review found sodium reduction resulted in mean arterial pressure (MAP) decrease of about 0.4 mmHg in white subjects with normal BP and a MAP decrease of about 4 mmHg in white subjects with... Read Summary Type: Systematic Reviews (Add filter) Type: Medicines Current Awareness (Remove filter)